Inhibition of angiogenesis
AssigneeGenentech, Inc.
InventorsNapoleon Ferrara, Farbod Shojaei, Xiumin Wu, Cuiling Zhong
Life of this patent
Estimating the term…
Abstract
The present invention relates generally to the inhibition of inflammatory cell-mediated angiogenesis. In particular, the invention concerns the prevention or treatment of tumor angiogenesis, and the inhibition of tumor development, using Bv8 antagonists, such as anti-Bv8 antibodies.
Claims5
A method of tumor treatment in a human subject having a tumor refractory to treatment with a vascular endothelial growth factor (VEGF) antagonist, comprising administering to said human subject an effective amount of an anti-Bv8 antibody or an antigen-binding fragment thereof and an effective amount of an anti-VEGF antibody or an antigen-binding fragment thereof.
Dependencies are inferred from the claim text.