Substituted pyrazines as cadherin-11 inhibitors

A method of inhibiting cadherin-11 activity in a subject, comprising:

• administering to the subject an effective amount of a compound of the following formula:
• or a pharmaceutically acceptable salt thereof, wherein:
• R1 and R2 are hydrogen;
• R3, R4, R5, R6, R7, R8, R9, R11 and R12 are each independently selected from hydrogen, halogen, hydroxy, substituted or unsubstituted alkoxy, substituted or unsubstituted amido, substituted or unsubstituted amino, substituted carbonyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, unsubstituted heteroalkyl, substituted or unsubstituted heteroalkenyl, substituted or unsubstituted heteroalkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkynyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkenyl, substituted or unsubstituted heterocycloalkynyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;
• R10 is selected from halogen, hydroxy, substituted alkoxy, substituted or unsubstituted amido, substituted or unsubstituted amino, substituted carbonyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, unsubstituted heteroalkyl, substituted or unsubstituted heteroalkenyl, substituted or unsubstituted heteroalkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkynyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkenyl, substituted or unsubstituted heterocycloalkynyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• and
• X1 and X2 are each N,
• wherein when one or more of R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are substituted, the substituent is selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, heteroalkyl, heteroalkenyl, heteroalkynyl, heteroaryl, cycloalkyl, cycloalkenyl, cycloalkynyl, heterocycloalkyl, heterocycloalkenyl, and heterocycloalkynyl.