Identification of a west nile virus CD4 T cell epitope and use thereof
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsGwong-Jen J. Chang, Holly R. Hughes
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Abstract
Described herein is the identification and of a potent West Nile virus (WNV) CD4 positive T cell epitope and its use for increasing the immunogenicity of heterologous flavivirus vaccines, such as dengue virus type 2 (DENV-2) DNA and virus-like particle (VLP) vaccines. Also described are methods for the identification of potent T cell epitopes to enhance immunogenicity of multivalent vaccines.
Claims14
An isolated mutant flavivirus E-glycoprotein polypeptide, wherein the polypeptide comprises an isoleucine at position 474, a threonine at position 484, a valine at position 488 and a leucine at position 493, each numbered with reference to the West Nile virus E-glycoprotein polypeptide sequence of SEQ ID NO:
- 38, wherein the amino acid sequence of the polypeptide comprises SEQ ID NO:
- 12, SEQ ID NO:
- 23, SEQ ID NO:
- 24, SEQ ID NO:
- 25, SEQ ID NO:
- 26, SEQ ID NO:
- 27, SEQ ID NO:
- 28, SEQ ID NO:
- 29, SEQ ID NO:
- 30 or SEQ ID NO:
- 31.
Dependencies are inferred from the claim text.