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US 9,284,355 B2Granted
Herpes simplex virus combined subunit vaccines and methods of use thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsHarvey Friedman, Sita Awashi, John Lubinski
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Abstract
This invention provides vaccines comprising two or more recombinant Herpes Simplex Virus (HSV) proteins selected from a gD protein, a gC protein and a gE protein; and methods of vaccinating a subject against HSV and treating, impeding, inhibiting, reducing the incidence of, or suppressing an HSV infection or a symptom or manifestation thereof, comprising administration of a vaccine of the present invention.
Claims19
An immunogenic composition comprising:
- (a) a recombinant Herpes Simplex Virus-1 (HSV-1) glycoprotein D (gD) or immunogenic fragment thereof;
- (b) a recombinant HSV-1 glycoprotein C (gC) fragment, wherein said gC fragment comprises amino acids 26-457 of SEQ ID NO:
- 3;
- and
- (c) an adjuvant;
- wherein the glycoprotein(s) of (a) and/or (b) is/are fused to an antigenic tag, and
- wherein said immunogenic composition does not comprise HSV-1 glycoprotein B (gB).
4 more elements
Dependencies are inferred from the claim text.