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US 9,284,354 B2Granted
Immunoglobulin-binding polypeptide
AssigneeKaneka Corporation
InventorsShinichi Yoshida, Dai Murata, Shunichi Taira
Life of this patent
Estimating the term…
Abstract
An object of the present invention is to provide novel polypeptides that are capable of binding to an immunoglobulin and have high stability against alkali. The present invention relates to proteins having the amino acid sequence of SEQ ID No:1 or 2.
Claims4
A polypeptide, that binds to a protein comprising an Fc region of an immunoglobulin, the polypeptide comprising the following amino acid sequence:
- (SEQ ID NO:
- 47)
- RFX1X2EQQNAFYEILHX3PNLTEEQRNX4FIQX5LX6X7X8PSVSREX9L
- AEAX10X11LNDAQAPX12
- wherein X1 is D, E, N, or Q;
- X2 is E or R;
- X3 is L, M, or I;
- X4 is A, E, F, R, Y, or W;
- X5 is D, E, H, I, L, Q, R, S, T, or V;
- X6 is H, I, or R;
- X7 is D, I, or R;
- X8 is D or E;
- X9 is I, L, or V;
- X10 is R or Q;
- X11 is H or R;
- and
- X12 is R, G, or K.
14 more elements
A polypeptide, that binds to a protein comprising an Fc region of an immunoglobulin, the polypeptide comprising the following amino acid sequence:
- (SEQ ID NO:
- 48)
- Z1Z2Z3RFX1X2EQQNAFYEILHX3PNLTEEQRNX4FIQX5LX6X7X8PSVS
- REX9LAEAX10X11LNDAQAPX12
- wherein X1 is D, E, N, or Q;
- X2 is E or R;
- X3 is L, M, or I;
- X4 is A, E, F, R, Y, or W;
- X5 is D, E, H, I, L, Q, R, S, T, or V;
- X6 is H, I, or R;
- X7 is D, I, or R;
- X8 is D or E;
- X9 is I, L, or V;
- X10 is R or Q;
- X11 is H or R;
- X12 is R, G, or K;
- and
- Z1 to Z3 are each independently A, D, E, G, H, I, L, N, Q, R, S, T, V, or Y.
15 more elements
Dependencies are inferred from the claim text.