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US 9,284,351 B2Granted
Dispersion and detachment of cell aggregates
AssigneeHutchison Biofilm Medical Solutions Ltd.
InventorAmir Zlotkin
Life of this patent
Estimating the term…
Abstract
Compositions comprising a protein or isolated peptide, and methods using the same for preventing, dispersing or detaching a biofilm, are disclosed.
Claims10
A cyclic peptide consisting of:
- a) the amino acid sequence X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12 (SEQ ID NO:
- 3), wherein X1 is S, N, T, K, R, H, E, I, Q or D;
- X2 is V, I, L, Y, G, F or W;
- X3 is H, N, Q, E, D or S;
- X4 is S, P, A or T;
- X5 is F, W or Y;
- X6 is D, N, E or Q;
- X7 is Y, F or W;
- X8 is D, G or E;
- X9 is W, F or Y;
- X10 is Y, F or W;
- X11 is N or Q;
- and X12 is V, I or L;
- and b) a cyclization linker between X1 and X12, wherein the peptide is not SVHSFDYDWYNV (SEQ ID NO:
- 4), and wherein the cyclic peptide has a total length of up to 50 amino acids.
12 more elements
Dependencies are inferred from the claim text.