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US 9,284,337 B2Granted
Small molecule enhancer for dendritic cell cancer vaccines
AssigneeTrustees of Tufts College
InventorWilliam W. Bachovchin
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AssigneeTrustees of Tufts College
InventorWilliam W. Bachovchin
Estimating the term…
Disclosed is a method of treating cancer, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound that inhibits a plurality of mammalian dipeptidyl peptidase (DPP) IV activity and/or structural homologues thereof (DASH) serine proteases. Also disclosed is a method of (a) increasing antitumor immunity, (b) stimulating or enhancing an immune response, (c) treating a condition characterized by abnormal cell proliferation, (d) increasing cytokine and/or chemokine production, or (e) stimulating or enhancing production of T-cells, in a mammal, comprising administering to a mammal in need thereof an effective amount of a compound that inhibits a plurality of mammalian DASH serine proteases. For example, the compound that inhibits a plurality of mammalian DASH serine proteases may be t-butylGly-boroPro.
A method of treating cancer, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound represented by:
A method of increasing antitumor immunity in a mammal, comprising administering to a mammal in need thereof an effective amount of a compound represented by:
A method of stimulating or enhancing an immune response in a mammal, comprising administering to a mammal in need thereof an effective amount of a compound represented by:
A method of treating a condition characterized by abnormal cell proliferation, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound represented by:
A method of increasing cytokine and/or chemokine production in a mammal, comprising administering to a mammal in need thereof an effective amount of a compound represented by:
A method of stimulating or enhancing production of T-cells in a mammal, wherein said T-cells recognize an antigen on a malignat cell, comprising administering to a mammal in need thereof an effective amount of a compound represented by:
Dependencies are inferred from the claim text.