Process for the preparation of imidazo[2,1-B][1,3]benzothiazole derivatives
AssigneeAmbit Biosciences Corporation
InventorsTimothy David Gross, Rathan Prasad Achampeta, Janakiram Rao Citineni
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Abstract
Provided herein are process for the preparation of N-(5-ferf-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-fe][1,3]benzothiazol-2-yl]phenyl}urea, or a pharmaceutically acceptable salt, solvate, hydrate, or polymorph thereof. N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-&][1,3]benzo-thiazol-2-yl]phenyl}urea is useful for treating, preventing, and/or managing diseases or conditions, including but not limited to, proliferative diseases, FLT-3 mediated diseases, and cancers. N-(5-ferf-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-&][1,3]benzothiazol-2-yl]phenyl}urea is represented by the structure:
Claims50
A process for the preparation of N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, or a pharmaceutically acceptable salt, solvate, hydrate, or polymorph thereof, comprising the step of reacting 7-(2-morpholin-4-yl-ethoxy)-2-(4-aminophenyl)imidazo[2,1-b]benzothiazole with a 5-tert-butylisoxazol-3-ylcarbamate of Formula (X),
- wherein R2 is aryl or heteroaryl, each of which is optionally substituted with one or more halo, nitro, cyano, alkyl or alkoxyl, to yield N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzo-thiazol-2-yl]phenyl}urea, wherein the reaction is carried out in an aprotic solvent.
Dependencies are inferred from the claim text.