1,4-dihydro-naphthyridine derivative and pharmaceutical composition and use thereof

A compound or pharmaceutically acceptable salt thereof, selected from the group consisting of:

• Compound 1:
• 5-amino-4-(2-chlorphenyl)-2,7,7-trimethyl-1,4,6,7,8,9-hexahydrobenzo[b][1,8]naphthyridine-3-carboxylic acid ethyl ester, as shown by S1;
• Compound 3:
• 5-amino-4-(3-fluorophenyl)-2,7,7-trimethyl-1,4,6,7,8,9-hexahydrobenzo[b][1,8]naphthyridine-3-carboxylic acid isopropyl ester, as shown by S3;
• Compound 6:
• 5-amino-4-(3-chlorphenyl)-2,7,7-trimethyl-1,4,6,7,8,9-hexahydrobenzo[b][1,8]naphthyridine-3-carboxylic acid ethyl ester, as shown by S6;
• Compound 8:
• 5-amino-4-(2-fluorophenyl)-2,7,7-trimethyl-1,4,6,7,8,9-hexahydrobenzo[b][1,8]naphthyridine-3-carboxylic acid isopropyl ester, as shown by S8;
• Compound 10:
• 5-amino-4-(2-chlorphenyl)-2,7,7-trimethyl-1,4,6,7,8,9-hexahydrobenzo[b][1,8]naphthyridine-3-carboxylic acid methoxylethyl ester, as shown by S10;
• Compound 15:
• 5-amino-4-(3-nitrophenyl)-2,9-dimethyl-1,4,6,7,8,9-hexahydrobenzo[b][1,8]naphthyridine-3-carboxylic acid methyl ester, as shown by S15;
• Compound 20:
• 5-amino-7,7-dichloro-2-methyl-4-(3-nitrophenyl)-1,4,6,7,8,9-hexahydrobenzo[b][1,8]naphthyridine-3-carboxylic acid ethyl ester, as shown by S20;
• Compound 27:
• 5-amino-4-(2,3-dichlorophenyl)-2,7-dimethyl-1,4,6,7,8,9-hexahydrobenzo[b][1,8]naphthyridine-3-carboxylic acid methyl ester, as shown by S27;
• Compound 32:
• 5-amino-2,7,7-trimethyl-4-(2-chlorphenyl)-1,4,6,7,8,9-hexahydrobenzo[b][1,8]naphthyridine-3-carboxylic acid isopropyl ester, as shown by S32.