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US 9,284,327 B2Granted
Taxane compounds, compositions and methods
AssigneeGfv, LLC
InventorsJohn K. Thottathil, Raymond P. Warrell
Life of this patent
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Abstract
The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
Claims15
A compound having the formula:
- (TT)m.(HX)n.(H2O)y.(Sol)z
- wherein TT is tesetaxel;
- HX is an acid selected from benzoic acid, ortho-toluic acid, meta-toluic acid, para-toluic acid, ethane sulphonic acid, camphor sulphonic acid, (S)-(+)-mandelic acid, (R)-(−)-mandelic acid, gentisic acid, hippuric acid, glycolic acid, 2-hydroxyethanesulfonic acid, 2-naphthalenesulfonic acid, gluconic acid, malic acid, oxalic acid, succinic acid, tartaric acid, malonic acid, adipic acid, itaconic acid, cyclohexane dicarboxylic acid, phthalic acid, edisylate, phenyl phosphonic acid, digluconic acid, dibasic natural amino acids, or phosphoric acid;
- Sol is an organic solvent;
- m and n are each independently an integer from about 1 to about 5;
- and
- y and z are each independently an integer from 0 to about 5.
4 more elements
A compound having the formula:
- (TT)m.(HX)n.(H2O)y.(Sol)z
- wherein TT is tesetaxel;
- HX is a monobasic, dibasic, tribasic, or polybasic acid;
- Sol is isopropyl alcohol;
- m and n are each independently an integer from about 1 to about 5;
- and
- y and z are each independently an integer from 0 to about 5.
4 more elements
Dependencies are inferred from the claim text.