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US 9,284,322 B2Granted
Nicotinic receptor compounds
AssigneeResearch Triangle Institute
InventorsFrank Ivy Carroll, Pauline Wanjiku Ondachi
Life of this patent
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Abstract
Provided herein are compounds and methods of preparation of compounds that are capable of functioning as agonists or antagonists of a nicotinic receptor. Also provided are pharmaceutical compositions comprising one or more of these compounds, which may further comprise one or more additional therapeutic agents. Further provided are methods of treatment of various conditions that may be responsive to such activity at the nicotinic receptors, such as nicotine dependence.
Claims14
A compound according to the structure:
- wherein:
- A is —R, —N(R)2, —C(═NR)N(R)2, or —OR,
- each R is, independently, H, alkyl, alkenyl, alkynyl, aryl, or aralkyl;
- each X is, independently, H, halo, alkyl, alkenyl, alkynyl, aralkyl, —OR, —CH2—CO2R, —C(O)R, —CO2R, —N(R)2, —NR—C(O)R, —C(O)N(R)2, —NR—CO2R, —SO3CF3, —NO2, —N3, —CF3, —CH═CHY, or —CN;
- Y is halo;
- n is an integer from 0-3;
- and
- R1 is a substituted pyridine having one or more substituents including at least one CONR12R13 substituent, wherein R12 and R13 are independently selected from H and C1-10 alkyl;
- or a pharmaceutically acceptable salt or stereoisomer thereof.
6 more elements
Dependencies are inferred from the claim text.