US 9,284,321 B2 · Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one

Abstract

The present invention relates to compounds of general formula I or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, R and n are as defined herein. The compounds may be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of neuro-active drugs, such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.

Claims14

Dependent claims

A compound of formula I

wherein
R1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkoxy substituted by halogen or cyano;
R2 is hydrogen, lower alkyl or lower alkyl substituted by halogen;
R3 is phenyl, benzo[1,3]dioxolyl, 2,3-dihydro-benzofuran-5-yl or a 5- and 6-membered heteroaryl, wherein phenyl and the 5- and 6-membered heteroaryl groups may be substituted by one or more substituents, selected from cyano, nitro, amino and lower di-alkylamino, lower alkyl sulfonyl, lower alkoxy, lower alkoxy substituted by halogen, halogen, lower alkyl, lower alkyl substituted by halogen or lower alkyl substituted by hydroxyl;
X is —CH(lower alkyl)-, —CH2—, —CH2CH2— or —CH(lower alkyl)CH2—;
R is hydrogen or lower alkyl;
n is 1 or 2;
or a pharmaceutically acceptable acid addition salt, a racemic mixture or its corresponding enantiomer and/or optical isomers thereof.

5 more elements

Dependencies are inferred from the claim text.

Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one

Life of this patent

Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one

Life of this patent

Abstract

Claims14