Protein kinase inhibitors

A compound of the Formula 1:

• wherein m is an integer from 0 to 1;
• n is an integer from 0 to 2;
• R1 is selected from alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl, wherein the aryl and heteroaryl may be further substituted by the groups selected from:
• 1) Halogen,
• 2) Alkoxyl,
• 3) Amino,
• 4) —N(H)C(O)O-alkyl,
• 5) —N(H)SO2-aryl,
• 6) —N(H)SO2-heteroaryl,
• 7) —N(H)CON(H)-aryl,
• 8) and —N(H)CON(H)-heteroaryl;
• R2a, R2b, R2c, R2d, R2e, R2f are independently selected from hydrogen, alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl;
• R2a and R2b, R2c and R2d, or R2e and R2f can be fused to form a 3 to 8 membered cycloalkyl or heterocyclyl ring system;
• X is selected CH2, O, S(O)n, and NR3;
• R3 is selected from hydrogen, alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, .C(O)R4, —C(O)OR4, S(O)2R4, C(O)NR4R5, —S(O)2NR4R5, and —C(S)NR4R5;
• and
• R4 and R5 are independently selected from alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl, or R4 and R5 can be fused to form a 3 to 8 membered heterocyclyl ring system.