Substituted imidazo[1,2-a]pyrazines as MPS-1 inhibitors

A compound of formula (I):

• in which:
• R1 represents a *CH2—Z moiety, * indicating the point of attachment with the rest of the molecule,
• wherein Z is a hydrogen atom, or a C1-C6-alkyl-, —(CH2)m—C2-C6-alkenyl, —(CH2)n—C2-C6-alkynyl, —(CH2)m—C3-C6-cycloalkyl, —(CH2)m-(3- to 7-membered heterocycloalkyl), aryl-C1-C6-alkyl, heteroaryl-C1-C6-alkyl-, halo-C1-C6-alkyl-, R′(R″)N—C1-C6-alkyl, HO—C1-C6-alkyl-, H2N—C1-C6-alkyl-, —C1-C6-alkyl-CN, C1-C6-alkoxy-C1-C6-alkyl-, halo-C1-C6-alkoxy-C1-C6-alkyl-, C3-C6-cycloalkyl-, a 3- to 7-membered heterocycloalkyl-, C2-C6-alkenyl-, C4-C8-cycloalkenyl-, C2-C6-alkynyl-, aryl- or heteroaryl- group;
• said C1-C6-alkyl-, —(CH2)m—C2-C6-alkenyl, —(CH2)n—C2-C6-alkynyl, —(CH2)m—C3-C6-cycloalkyl, —(CH2)m-(3- to 7-membered heterocycloalkyl), aryl-C1-C6-alkyl-, heteroaryl-C1-C6-alkyl-, halo-C1-C6-alkyl-, R′(R″)N—C1-C6-alkyl-, HO—C1-C6-alkyl-, H2N—C1-C6-alkyl-, —C1-C6-alkyl-CN, C1-C6-alkoxy-C1-C6-alkyl-, halo-C1-C6-alkoxy-C1-C6-alkyl-, C3-C6-cycloalkyl-, a 3- to 7-membered heterocycloalkyl-, C2-C6-alkenyl-, C4-C8-cycloalkenyl-, C2-C6-alkynyl-, aryl- or heteroaryl- group, is optionally substituted, identically or differently, with 1, 2, 3, or 4 R7 groups;
• R2 represents a
• group,
• in which * indicates the point of attachment with the rest of the molecule, and in which
• R6a, R6b, R6c, and R6d
• represent, independently from each other, a hydrogen or halogen atom, or a —CN, C1-C6-alkyl-, C1-C6-alkoxy-, halo-C1-C6-alkyl-, R(R′)N—C1-C6-alkyl-, HO—C1-C6-alkyl-, C1-C6-alkoxy-C1-C6-alkyl-, halo-C1-C6-alkoxy-C1-C6-alkyl-, —C(═O)R, —C(═O)N(H)R, —C(═O)N(R)R′, —C(═O)O—R, —N(R)R′, —NO2, —N(H)C(═O)R, —N(R)C(═O)R′, —N(H)C(═O)N(R)R′, —N(R)C(═O)N(R′)R″, —N(H)C(═O)OR, —N(R)C(═O)OR′, —N(H)S(═O)R′, —N(R)S(═O)R′, —N(H)S(═O)2R, —N(R)S(═O)2R′, —N═S(═O)(R)R′, —OR, —O(C═O)R, —O(C═O)N(R)R′, —O(C═O)OR, —SR, —S(═O)R, —S(═O)N(H)R, —S(═O)N(R)R′, —S(═O)2R, —S(═O)2N(H)R, —S(═O)2N(R)R′, —S(═O)(═NR)R′ group;
• and
• R6e represents a cyclopropyl-group being optionally substituted, identically or differently, with 1, 2, 3, or 4 groups selected from:
• hydrogen, halogen, —OH, —CN, C1-C6-alkyl-, —C1-C6-alkoxy, halo-C1-C6-alkyl-;
• R3 represents a —N(H)C(═O)R or a
• group, wherein
• * indicates the point of attachment with the rest of the molecule;
• said —N(H)C(═O)R or
• group,
• being optionally substituted, identically or differently, with 1, 2, 3, or 4 R8 groups;
• R4 represents a hydrogen or halogen atom, or a —CN, C1-C6-alkyl- or aryl-group;
• R5 represents a hydrogen atom;
• R7 represents a hydrogen or halogen atom, or a —CN, HO—, C1-C6-alkoxy-, C1-C6-alkyl-, halo-C1-C6-alkyl-, halo-C1-C6-alkoxy- R(R′)N—C1-C6-alkyl-, HO—C1-C6-alkyl, HO—C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl-, halo-C1-C6-alkoxy-C1-C6-alkyl-, C2-C6-alkenyl, 3- to 7-membered heterocycloalkyl, aryl-, heteroaryl-, —C(═O)R, —C(═O)N(H)R,
• —C(═O)N(R)R′, —C(═O)O—R, —N(R)R′, —NO2, —N(H)C(═O)R, —N(R)C(═O)R′, —N(H)C(═O)N(R)R′, —N(R)C(═O)N(R′)R″, —N(H)C(═O)OR, —N(R)C(═O)OR′, —N(H)S(═O)R, —N(R)S(═O)R′, —N(H)S(═O)2R, —N(R)S(═O)2R′, —N═S(═O)(R)R′, —OR, —O(C═O)R, —O(C═O)N(R)R′, —O(C═O)OR, —SR, —S(═O)R, —S(═O)N(H)R, —S(═O)N(R)R′, —S(═O)2R, —S(═O)2N(H)R, —S(═O)2N(R)R′, —S(═O)(═NR)R′, —S(═O)2-(3- to 7-membered heterocycloalkyl) group;
• wherein said 3- to 7-membered heterocycloalkyl- or heteroaryl-, is optionally substituted, identically or differently, with 1, 2, 3, or 4 C1-C6-alkyl- groups
• R8 represents a hydrogen or halogen atom, or a —CN, HO—, C1-C6-alkoxy-, halo-C1-C6-alkoxy-, C1-C6-alkyl-, —C1-C6-alkyl-N(H)C(═O)R, —C1-C6-alkyl-C(═O)N(H)R, —C1-C6-alkyl-C(═O)OR, halo-C1-C6-alkyl-, R(R′)N—C1-C6-alkyl-, HO—C1-C6-alkyl, HO—C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl-, halo-C1-C6-alkoxy-C1-C6-alkyl-, —C2-C6-alkenyl, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, —C(═O)R, —C(═O)N(H)R, —C(═O)N(R)R′, —C(═O)O—R, —N(R)R′, —NO2, —N(H)C(═O)R, —N(R)C(═O)R′, —N(H)C(═O)N(R)R′, —N(R)C(═O)N(R′)R″, —N(H)C(═O)OR, N(R)C(═O)OR′, —N(H)S(═O)R, —N(R)S(═O)R′, —N(H)S(═O)2R, —N(R)S(═O)2R′, —N═S(═O)(R)R′, —OR, —O(C═O)R, —O(C═O)N(R)R′, —O(C═O)OR, —SR, —S(═O)R, —S(═O)N(H)R, —S(═O)N(R)R′, —S(═O2)R, —S(═O)2N(H)R, —S(═O)2N(R)R′, —S(═O)(═NR)R′, —S(═O)2-(3- to 7-membered heterocycloalkyl) group;
• R, R′ and R″ are, independently from each other, a hydrogen atom or a C1-C6-alkyl-, —C3-C6-cycloalkyl, C3-C6-alkenyl-, aryl- or a heteroaryl- group;
• m is 0, 1, 2, 3, 4, 5 or 6;
• and
• n is 1, 2, 3, 4 or 5;
• or a stereoisomer, a tautomer, an N-oxide, or a pharmaceutically acceptable salt thereof, or a mixture of same.