N-methyl tetrahydroquinoline M1 receptor positive allosteric modulators

A compound of formula (I):

• and pharmaceutically acceptable salts thereof, wherein
• --- represents a bond which can be absent or present,
• Y is selected from the group consisting of
• (1) a C5-10 heterocycle group, said heterocycle optionally substituted with 1 to 3 groups of R1, and
• (2) C6-10 aryl group, said aryl optionally substituted with 1 to 3 groups of R1,
• X and X1 are independently selected from —CH2 and —O—;
• R1 is selected from the group consisting of
• (1) hydrogen,
• (2) C6-10aryl,
• (3) C5-10 heterocycle,
• (4) (CH2)nhalogen,
• (5) —CN,
• (6) —O—C1-6 alkyl,
• (7) —C1-6 alkyl,
• (8) —C2-6 alkenyl
• (9) —S(═O)n—R2,
• (10) —(C(O)O)mNR3AR3B,
• (11) —OH,
• (12) -oxo,
• (13) —C(═O)—(O)m—R4,
• (14) CF3,
• wherein said aryl, heterocycle, alkyl and alkenyl moiety is optionally substituted with one to three of
• (a) halogen,
• (b) hydroxy,
• (c) —O—C1-6 alkyl,
• (d) —C1-6 alkyl,
• (e) —C(═O)—(O)m—R4,
• (f) —N(R3AR3B),
• (g) —S(═O)n—R5, or
• (h) C5-10heteroaryl, which is optionally substituted with 1 to 3 groups of C1-6 alkyl,
• R2, R4, and R5 are independently selected from the group consisting of
• (1) hydrogen,
• (2) —C1-6 alkyl,
• (3) —C2-6 alkenyl, and
• (3) —(CH2)n-aryl,
• (4) —N(R1)2
• wherein said R2, R4 and R5 alkyl or aryl moiety is optionally substituted with one or more
• (a) halogen,
• (b) cyano, and
• (c) —O—C1-6 alkyl, wherein said alkyl is optionally substituted with one or more halogen;
• R3A and R3B are selected from the group consisting of
• (1) hydrogen,
• (2) —C1-6 alkyl,
• (3) —C3-6 cycloalkyl,
• (4) —C(═O)—O—R4,
• (5) —S(O)2—R4,
• or R3A and R3B are linked together with the nitrogen to which they are both attached to form a 2-6 membered carbocyclic ring, wherein one or two of the ring carbon atoms is optionally replaced by a nitrogen, oxygen or sulfur;
• m is 0 or 1;
• and
• n is 0, 1 or 2.