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US 9,284,310 B2Granted
Inhibitors of cytomegalovirus
AssigneeBoehringer Ingelheim International GmbH
InventorsLee Fader, Francois Bilodeau, Mathieu Parisien, Maude Poirier, Cyrille Kuhn, Carl Thibeault, Thao Trinh
Life of this patent
Estimating the term…
Abstract
Compounds of Formula (I) wherein n, R1, R1A, R2, R3, Y and Z are defined herein, are useful for the treatment of cytomegalovirus disease and/or infection.
Claims17
A compound of Formula (I) or racemate, enantiomer, diastereomer or tautomer thereof:
- wherein
- R1 is S or O;
- R1A is CH or N;
- Ring Z is selected from the group consisting of phenyl, pyridine and pyridinone, wherein said phenyl, pyridine and pyridinone are each optionally mono-, di- or tri-substituted with (C1-6)alkyl or —O—(C1-6)alkyl;
- Ring Y is selected from the group consisting of imidazole, triazole and pyridine, wherein said imidazole, triazole and pyridine are each optionally mono-, di- or tri- substituted with halo, —CN, OH, —O—(C1-6)alkyl, —C(═O)NH2, (C1-6)haloalkyl, (C2-6)alkenyl, (C2-6)alkynyl or (C1-6)alkyl optionally mono- or di-substituted with OH, —C(═O)NH2, —C(═O)OH, Y1, —O—(C1-6)alkyl-Y1 or —N(H)—(C1-6)alkyl)-Y1;
- Y1 is aryl, heterocycle or heteroaryl, wherein said aryl, heterocycle or heteroaryl are each optionally mono-, di- or tri-substituted with halo, —CN, OH, —O—(C1-6)alkyl, (C1-6)haloalkyl or (C1-6)alkyl;
- R2 is absent, (C1-6)alkyl, (C3-7)cycloalkyl, —O, *—N(R2A)—C(═O)— §, *—N(R2A)—C(═O)—(C3-7)cycloalkyl-§, *—N(R2A)—C(═O)—(C1-6)alkyl-§ (wherein, when necessary, the site of attachment to the Y ring is indicated with an * and the site of attachment to the phenyl ring is indicated with a §);
- wherein each said alkyl is optionally mono-, di- or tri-substituted with substituents independently selected from the group consisting of OH, —O—(C1-6)alkyl, —O-aryl and —O—(C1-6)alkyl-aryl;
- R2A is H or (C1-6)alkyl;
- R3 is halo, (C1-6)haloalkyl, —CN, OH, —O—(C1-6)alkyl or (C1-6)alkyl,
- wherein each said alkyl is optionally mono- or di-substituted with OH, C(═O)OH, aryl, heterocycle or heteroaryl;
- n is 0, 1, 2 or 3;
- or a salt thereof.
10 more elements
Dependencies are inferred from the claim text.