Methylene linked quinolinyl modulators of RORγt

A compound of Formula I wherein:

• R1 is azetidinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl, pyridyl, pyridyl N-oxide, pyrazinyl, pyrimidinyl, pyridazyl, piperidinyl, tetrahydropyranyl, phenyl, oxazolyl, isoxazolyl, thiophenyl, benzoxazolyl, or quinolinyl;
• wherein said piperidinyl, pyridyl, pyridyl N-oxide, imidazolyl, phenyl, thiophenyl, benzoxazolyl, and pyrazolyl are optionally substituted with SO2CH3, C(O)CH3, C(O)NH2, CH3, CH2CH3, CF3, Cl, F, —CN, OCH3, N(CH3)2, —(CH2)3OCH3, SCH3, OH, CO2H, CO2C(CH3)3, or OCH2OCH3;
• and optionally substituted with up to two additional substituents independently selected from the group consisting of Cl, OCH3, and CH3;
• and wherein said triazolyl, oxazolyl, isoxazolyl, and thiazolyl are optionally substituted with one or two CH3 groups;
• and wherein said azetidinyl is optionally substituted with CO2C(CH3)3, C(O)NH2, CH3, SO2CH3, or C(O)CH3;
• R2 is 1-methyl-1,2,3-triazolyl, pyridyl, pyridyl-N-oxide, 1-methyl pyrazol-4-yl, pyrimidin-5-yl, pyridazyl, pyrazin-2-yl, oxazolyl, isoxazolyl, N-acetyl-azetidin-3-yl, N-methylsulfonyl-azetidin-3-yl, N-Boc-azetidin-3-yl, N-methyl-azetidin-3-yl, N-acetamidyl-azetidin-3-yl, 1-H-azetidin-3-yl, N-acetyl piperidinyl, 1-H-piperidinyl, N-Boc-piperidinyl, N—C(1-2)alkyl-piperidinyl, thiazol-5-yl, 1-(3-methoxypropyl)-imidazol-5-yl, or 1-C(1-2)alkyl imidazol-5-yl;
• wherein said 1-C(1-2)alkyl imidazol-5-yl is optionally substituted with up to two additional CH3 groups, or one substituent selected from the group consisting of SCH3, and Cl;
• and said pyridyl, and pyridyl-N-oxide are optionally substituted with up to two substituents independently selected from the group consisting of C(O)NH2, —CN, OCH3, CF3, Cl, and CH3;
• and said thiazol-5-yl, oxazolyl, and isoxazolyl are optionally substituted with up to two CH3 groups;
• and said 1-methyl pyrazol-4-yl is optionally substituted with up to two additional CH3 groups;
• R3 is H, OH, OCH3, NHCH3, N(CH3)2, or NH2;
• R4 is H, or F;
• R5 is H, Cl, —CN, CF3, SCH3, OC(1-3)alkyl, OH, C(1-4)alkyl, N(CH3)OCH3, NH(C(1-2)alkyl), N(C(1-2)alkyl)2, NH-cyclopropyl, OCHF2, 4-hydroxy-piperidinyl, azetidin-1-yl, or fur-2-yl;
• R6 is pyridyl, pyrimidinyl, phenyl, benzothiophenyl, or thiophenyl;
• wherein said pyridyl or phenyl is optionally substituted with N(CH3)2, SCH3, OCF3, SO2CH3, CF3, CHF2, imidazol-1-yl, pyrazol-1-yl, 1,2,4-triazol-1-yl, CH3, OCH3, Cl, F, or —CN;
• and said thiophenyl is optionally substituted with CF3;
• R7 is H, Cl, —CN, C(1-4)alkyl, OCH2CF3, OCH2CH2OCH3, CF3, SCH3, SO2CH3, OCHF2, NA1A2, C(O)NHCH3, N(CH3)CH2CH2NA1A2, OCH2CH2NA1A2, OC(1-3)alkyl, OCH2-(1-methyl)-imidazol-2-yl, imidazol-2-yl, fur-2-yl, pyrazol-1-yl, pyrazol-4-yl, pyrid-3-yl, or pyrimidin-5-yl;
• thiophen-3-yl, 1-methyl-indazol-5-yl, 1-methyl-indazol-6-yl, phenyl, or
• wherein said imidazolyl or pyrazolyl can be optionally substituted with a CH3 group;
• A1 is H or C(1-4)alkyl;
• A2 is H, C(1-4)alkyl, cyclopropyl, C(1-4)alkylOC(1-4)alkyl, C(1-4)alkylOH, C(O)C(1-2)alkyl, or OCH3;
• or A1 and A2 may be taken together with their attached nitrogen to form a ring selected from the group consisting of:
• Ra is H, F, OCH3, or OH;
• Rb is CH3, or phenyl;
• R8 is H, CH3, OCH3, or F;
• R9 is H, or F;
• and pharmaceutically acceptable salts thereof;
• provided that (4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)bis(1,2,5-trimethyl-1H-imidazol-4-yl)methanol, N-(2-((3-(4-(1H-pyrazol-1-yl)benzyl)-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-hydroxyquinolin-2-yl)oxy)ethyl)acetamide, and (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-(4-methylpiperazin-1-yl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol are excluded from the claim.