Substituted pyrimidines as toll-like receptor modulators

A compound of formula (I)

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is hydrogen, fluoro, hydroxy, amino, C1-6 alkyl, C1-6 alkylamino, C1-6 alkoxy, C3-7 cycloalkyl, C4-7 heterocyclyl, aryl, bicyclic heterocyclyl, arylalkyl, heteroaryl, heteroarylalkyl, aryloxy, heteroaryloxy, carboxy, carboxy ester, or amido each of which is optionally substituted by one or more substituents independently selected from halo, hydroxy, amino, di-(C1-6)alkylamino, (C1-4)alkoxy-(C1-4)alkyl, C1-6 alkylamino, C1-6 alkyl, C1-6 alkoxy, C3-6 cycloalkyl, carboxy, carboxy ester, amido, heterocyclyl, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl, or cyano,
• R2 is C1-6 alkyl, which is optionally substituted by one or more substituents independently selected from halo, hydroxy, amino, cyano, carboxy, carboxy ester, amido, C1-3 alkyl, C1-3 alkoxy or C3-6 cycloalkyl,
• with the proviso that N-(2-amino-5-phenethylpyrimidin-4-yl)-N-pentylamine is excluded.