Sialochimeric compounds
AssigneeTherapicon SRL
InventorsPaolo Alberto Veronesi, Pablo E. A. Rodriguez, Anna Maria Veronesi, Emanuela Peschechera
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Abstract
The present invention discloses a new class of compounds that exhibit an inhibitory effect on influenza virus type A and B, which may or may not be resistant to other drugs, as well as on other types of viruses, such as flavivirus but also on protozoa and other micro-organisms, their preparation methods, pharmaceutical formulations containing them and their use as medicinal products for the treatment of various conditions caused by particular microorganisms, including viruses, bacteria and protozoa, which affect animal and human health.
Claims10
A compound of structural formula (I):
- wherein:
- X is —O—;
- R is —H;
- R1 is —(NH)-(T) or —NH—C(NH)—NH-(T), wherein-(T) is selected from
- wherein —R5 is —H, —CH3, —C2H5;
- —R6 is —NH—CO—CH3, —NH—CO—C2H5;
- and —R7 is —O—CH—(C2H5)2
- or
- or
- or
- wherein —Z is —H, —CH—(C2H5)2, —CO—(CH2)6—CH3;
- R2 is —OH;
- R3 is —NH—CO—CH3;
- R4 is, independently from R1, —CHOH—CHOH—CH2-0H, —(W), —CHOH—CH2-(W), or —CH2-(W);
- and —(W) is either:
- wherein:
- R8 is —NH—, —CH2—NH—, —CH(CH3)—NH—, C(CH3)2—CH2—NH—;
- R9 is —H, —CH3;
- R10 is —H, —CH3
- or
- wherein —R11 is —NH—, —CO—NH— or —C(NH)—NH—
- and linear or branched C1-4 carboxy mono or poly esters, addition salts, solvates, resolved enantiomers and purified diastereoisomers thereof.
A compound selected from the group consisting of the following structural formulae:
- and linear or branched C1-4 carboxy mono or poly esters, addition salts, solvates, resolved enantiomers and purified diastereoisomers thereof.
Dependencies are inferred from the claim text.