Kappa opioid receptor compounds

A method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety and addiction, the method comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of the formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• X1 is a group of the general formula (II):
• or
• X1 is a heteroaryl ring, selected from the list comprising 2-imidazolyl, 4-imidazolyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-2-yl, 1,2,4-thiadiazol-4-yl, 1,2,3-triazolyl-2-yl, 1,2,3-triazol-1-yl, 1,2,4-triazol-1-yl, 1,2,4-triazol-3-yl, 1,2,4-triazol-4-yl, 1,3-thiazol-2-yl, 1,3-thiazol-4-yl, 1,2,3,4-tetrazol-5-yl, 1,2,3,4-tetrazol-1-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-2-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, 1,3-pyrimidin-2-yl, 1,2-pyrazin-3-yl and 1,2,4-triazin-3-yl;
• R5, R6 and R7 are independently selected from the list consisting of H, C1-C6 alkyl, C3-C7-cycloalkyl, aryl and heteroaryl;
• or
• R5 and R6, taken together with the N—C═N group to which they are attached, form a 5-10 membered cyclic or bicyclic ring, optionally substituted with up to two additional heteroatoms selected from the group consisting of N, O and S;
• or
• R6 and R7 taken together with the nitrogen atom to which they are attached form a 5-10 membered cyclic or bicyclic ring, optionally substituted with up to two additional heteroatoms selected from the group consisting of N, O and S, and comprising the rings azetidine, pyrrolidine, piperidine, azepine, piperazine, morpholine and thiomorpholine;
• X2 is H, Cl or F;
• R1 and R2 are independently hydrogen or methyl;
• R3 is hydrogen;
• and
• n is zero, one or two.