Oxazine derivatives and their use in the treatment of disease

A compound of the formula (I), or a pharmaceutically acceptable salt thereof:

• wherein
• n represents 0 or 1;
• X represents CH or N;
• R1 represents:
• phenyl, optionally substituted by 1, 2 or 3 substituents independently selected from R10;
• a group G1 selected from furan-2-yl, pyridin-2-yl, pyrimidin-2-yl, pyrimidin-4-yl and pyrazin-2-yl, wherein G1 is optionally substituted by 1, 2 or 3 substituents independently selected from R10;
• or
• a group G2 selected from isothiazolo[4,5-b]pyridin-3-yl, isothiazolo[4,5-b]pyrazin-3-yl, benzo[d]isothiazol-3-yl, indazol-3-yl, benzo[d]isoxazol-3-yl, pyrido[3,2-d]pyrimidin-4-yl, [1,7]naphthyridin-8-yl and imidazol[1,2-a]pyrazin-8-yl, wherein G2 is optionally substituted by 1, 2 or 3 substituents independently selected from R11;
• R2, R3 and R4 independently represent hydrogen, halogen or C1-3alkyl;
• R5 represents C1-3alkyl, halogen-C1-3alkyl or C1-3alkoxy-C1-3alkyl;
• R6 and R7 independently represent hydrogen or C1-3alkyl;
• R8 and R9 independently represent hydrogen, C1-3alkyl, halogen-C1-3alkyl or C1-3alkoxy;
• or R8 and R9 taken together are cyclopropyl;
• R10 represents halogen, cyano, hydroxy, halogen-C1-3alkoxy, C1-3alkoxy, C1-3alkoxy-C1-3alkoxy, nitro or amino;
• and
• R11 represents halogen, cyano, hydroxy, halogen-C1-3alkyl, halogen-C1-3alkoxy, C1-3alkoxy, C1-3alkoxy-C1-3alkyl or C1-3alkoxy-C1-3alkoxy.