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US 9,284,274 B2Granted
Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
AssigneeRamot at Tel-Aviv University Ltd.
InventorsYoel Kashman, Eliezer Flescher, Max Herzberg
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Abstract
The present invention relates to novel jasmonate derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for prevention and treatment of cancers.
Claims17
A compound represented by the structure of Formula II:
- wherein
- A is COR1;
- R1 is an unsubstituted or substituted heteroaryloxy;
- R2 is oxo;
- R3, R4, R5, R6 and R7 are each hydrogen,
- wherein the bond between C9 and C10 can be a single or double bond;
- R15 and R16 are each hydrogen;
- and
- n is selected from 0, 1 and 2;
- including salts, hydrates, solvates, polymorphs, optical isomers, geometrical isomers, enantiomers, diastereomers, and mixtures thereof.
7 more elements
Dependencies are inferred from the claim text.