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AssigneeKorea Institute of Ocean Science & Technology
InventorsJoung Han Yim, Il Chan Kim, Dockyu Kim, Se Jong Han, Hyoung Seok Lee, Hari Datta Bhattarai, Tai Kyoung Kim, Keun Sik Kim
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Disclosed is a method of the synthesis of ramalin. It comprises reacting a glutamic acid derivative, which is prepared using alkylchloroformate, with a hydrazine salt compound, which is prepared from hydroxy aniline, whether protected or not. The synthesis method allows ramalin, excellent in antioxidant and anti-inflammatory activity, to be simply synthesized at stable yield even without use of a highly toxic solvent such as DMF. In addition, the method is cost competitive, and provides ramalin at high efficiency, thus enabling the mass production of ramalin.
A method of synthesizing ramalin, comprising:
A method of synthesizing a ramalin precursor, comprising reacting a glutamic acid derivative represented by the following Chemical Formula 2 with a hydrazine salt compound represented by the following Chemical Formula 3, thereby producing the ramalin precursor represented by the following Chemical Formula 4:
A method of synthesizing a compound of Chemical Formula 16, comprising reacting an amino acid derivative represented by the following Chemical Formula 17 with a hydrazine salt compound represented by the following Chemical Formula 18:
Dependencies are inferred from the claim text.