Cytosolic delivery of materials with endosome-disrupting colloids

A nanocrystal-cationic core-shell polymer colloid composition comprising a core having an outer shell and a nanocrystal conjugated to or assembled to the outer shell,

• wherein the core is comprised of a polymer of a first core monomer and a second core monomer, wherein the first core monomer, having the formula R1C(CH2)—C(O)—R2—R3—N(R4)R5, wherein R1 is H or alkyl, R2 is O or NH, R3 is an alkyl, and R4 and R5 are H or alkyl, is crosslinked to the second core monomer, the second core monomer having the formula R1C(CH2)—C(O)—R2—CH2—(CH2—O—CH2)n—CH2—R2—C(O)—C(CH2)R1, wherein R1 is H or alkyl, R2 is O or NH, and n is 1 to 50;
• wherein the outer shell is comprised of a polymer of a first and second shell monomers and the first and second core monomers, wherein the first shell monomer has the formula R1C(CH2)—C(O)—R2—R3—N(R4)R6, wherein R1 is H or alkyl, R2 is O or NH,R3is an alkyl, R4 is H or alkyl, and R6 is H, alkly, acyl, or C═(NH)2, and the second shell monomer has the formula R1C(CH2)—C(O)—R2—CH2—(CH2—O—CH2)n—CH2—R2—C(O)—C(CH2)R1, wherein R1 is H or alkyl, R2 is O or NH, and n is 1 to 50, wherein the second core monomer and second shell monomer can be the same or different, and wherein at least one of the first or second shell monomers further comprises at least one pendant amine group whereby functional groups can be attached.