Capillary ion chromatography
AssigneeDionex Corporation
InventorsYan Liu, Victor Manuel Berber Barreto, Christopher A. Pohl, Nebojsa Avdalovic
Life of this patent
Estimating the term…
Abstract
An apparatus for capillary ion chromatography comprising a suppressor comprising flow-through ion exchange packing in a housing and capillary tubing formed of a permselective ion exchange membrane, and at least partially disposed in said ion exchange packing. Also, a recycle conduit for aqueous liquid from the detector to the packing. Further, the capillary tubing may have weakly acidic or weakly basic functional groups. Also, a method for using the apparatus.
Claims19
An electrolytically-regenerated suppressor for capillary ion chromatography comprising:
- (a) a central chamber including:
- (i) an ion exchange packing;
- and
- (ii) a capillary tubing having an inlet and an outlet and formed of a permselective ion exchange membrane, the capillary tubing being at least partially disposed in the ion exchange packing;
- (b) a first electrode chamber having an inlet and an outlet, the first electrode chamber including:
- (i) a first electrode:
- (ii) a first permselective barrier that separates the first electrode chamber from the ion exchange packing;
- and
- (c) a second electrode chamber having an inlet and an outlet, the second electrode chamber including:
- (i) a second electrode;
- (ii) a second permselective barrier that separates the second electrode chamber from the ion exchange packing.
A method for suppressing ions in capillary chromatography, the method comprising:
- flowing an aqueous sample stream including separated sample ionic species of one charge, positive or negative, in an eluent, through a capillary tubing, the capillary tubing being formed of a permselective ion exchange membrane and at least partially disposed in an ion exchange packing;
- transporting counterions in the eluent of opposite charge to the sample ionic species across the tubing from an inner tubing wall to an outer tubing wall;
- flowing an aqueous regenerant liquid through the ion exchange packing past the outside of the tubing and to a first electrode chamber, the first electrode chamber including:
- a first electrode and a first permselective barrier that separates the first electrode chamber from the ion exchange packing;
- and
- flowing the aqueous regenerant liquid from the first electrode chamber to a second electrode chamber, the second electrode chamber including:
- a second electrode and a second permselective barrier that separates the second electrode chamber from the ion exchange packing.
A method for suppressing ions in capillary chromatography, the method comprising:
- flowing an aqueous sample stream including separated sample ionic species of one charge, positive or negative, in an eluent, through a capillary tubing, the capillary tubing being formed of a permselective ion exchange membrane and at least partially disposed in an ion exchange packing;
- transporting counterions in the eluent of opposite charge to the sample ionic species across the tubing from an inner tubing wall to an outer tubing wall;
- exchanging the transported counterions with ions on the ion exchange packing immediately adjacent to the outer tubing wall;
- flowing an aqueous regenerant liquid to a first electrode chamber, the first electrode chamber including:
- a first electrode and a first permselective barrier that separates the first electrode chamber from the ion exchange packing;
- and
- flowing the aqueous regenerant liquid from the first electrode chamber to a second electrode chamber, the second electrode chamber including:
- a second electrode and a second permselective barrier that separates the second electrode chamber from the ion exchange packing.
Dependencies are inferred from the claim text.