Agglomerated ion exchange particle bed and method
AssigneeDionex Corporation
InventorsChristopher A. Pohl, Charanjit Saini
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Abstract
A liquid chromatography agglomerated bed comprising component A comprising (a) substrate particles and polymer chains (e.g. a condensation polymer) bound to the substrate particles and projecting therefrom, and (b) component B comprising substrate particles having external surfaces of opposite charge to that of the charged polymer chains, components A and B being bound at least in part by electrostatic forces between the component A charged polymer chains and the component B external surfaces to form in composite an agglomerated bed of ion exchange particles packed in a chromatography column.
Claims11
An agglomerated particle bed comprising ion exchange particles, said bed being suitable for use as chromatographic packing and comprising:
- (a) component A comprising substrate particles and polymer chains of one charge, positive or negative, bound to said substrate particles, said component A polymer chains being formed by at least first and second condensation polymer reaction products of an amine and a polyfunctional compound, said first reaction product being attached to said component A substrate particles and comprising the reaction product of an amine and a polyfunctional compound, and said second reaction product being bound to said first reaction products, and
- (b) component B comprising substrate particles having external surfaces of opposite charge to that of said charged polymer chains, at least some of said component A and component B being bound at least in part by electrostatic forces between said component A charged polymer chains and said component B external surfaces forming, in composite, an agglomerated bed of ion exchange particles;
- the ratio of particle diameters of component A and component B being between 0.2:1 and 5:1.
An agglomerated bed comprising ion exchange particles, said bed being suitable for use as chromatographic packing and comprising:
- (a) component A comprising substrate particles and polymer chains of one charge, positive or negative, bound to said substrate particles, said component A polymer chains being formed by at least first and second condensation polymer reaction products of an amine and a polyfunctional compound, said first reaction product being attached to said component A substrate particles and comprising the reaction product of an amine and a polyfunctional compound, and said second reaction product being bound to said first reaction products, and
- (b) component B comprising substrate particles having external surfaces of opposite charge to that of said charged polymer chains, at least some of said component A and component B being bound at least in part by electrostatic forces between said component A charged polymer chains and said component B external surfaces forming, in composite, an agglomerated bed of ion exchange particles;
- the diameters of component A and component B varying by no more than 400%.
Dependencies are inferred from the claim text.