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US 9,283,389 B2Granted
Method of treating movement disorders of a living being
AssigneeEberhard-Karls-Universitat Tubingen Universitatsklinikum
InventorsRejko Krueger, Daniel Weiss
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Abstract
The present invention relates to a method of treating movement disorders of a living being, a method of treating refractory gait disturbances of a human Parkinson's disease patient being affected by gait disturbances, and an apparatus for deep brain stimulation (DBS) of a living being affected by movement disorders.
Claims15
Method of treating movement disorders of a living being, comprising the following steps:
- (a) subjecting a living being affected by movement disorders to a first deep brain stimulation (DBS) protocol for a first time period,
- (b) subjecting said living being to a second DBS protocol for a second time period following said first time period, and
- (c) repeating steps (a) and (b), wherein said first DBS protocol differs from said second DBS protocol, said first DBS protocol comprises the simultaneous delivery of electrical impulses to two different brain areas of said living being, wherein said first brain area is the subthalamic nucleus (STN) and said second brain area is the substantia nigra pars reticulate (SNr), and said second DBS protocol comprises the delivery of electrical impulses to one brain area of said living being, wherein said one brain area is the subthalamic nucleus (STN);
- wherein said first and said second time periods are determined by the activity states of said living being, said first time period is determined by the waking state, or activity state, or waking and activity states of said living being, and said second time period is determined by the sleeping state, or resting state, or sleeping and resting states of said living being.
1 more element
Method of treating refractory gait disturbances of a human Parkinson patient being affected by gait disturbances, comprising the following steps:
- (a) subjecting said patient for a first time period determined by the waking or activity period of said patient to a first deep brain stimulation (DBS) protocol comprising the simultaneous delivery of electrical impulses to the subthalamic nucleus (STN) and to the substantia nigra pars reticulate (SNr) in an alternating order (interleaved pulses),
- (b) subjecting said patient for a second time period determined by the sleeping or resting period of said patient, ending the first DBS protocol and subjecting said patient to a second DBS protocol comprising the delivery of electrical impulses to the subthalamic nucleus (STN), and
- (c) repeating steps (a) and (b).
Apparatus for deep brain stimulation (DBS) of a living being affected by movement disorders, comprising:
- an electrical pulse generator
- at least one electrode connected to the pulse generator, said electrode is adapted to simultaneously deliver electrical impulses to two different brain areas of a living being, and
- a control unit configured to control said electrical pulse generator to generate said electrical impulses,
- wherein the control unit is configured to control said pulse generator in accordance with a first DBS protocol for a first time period, and in accordance with a second DBS protocol for a second time period upon ending the first DBS protocol,
- wherein said control unit alternates between said first and second DBS protocols, said first DBS protocol differs from said second DBS protocol, said first DBS protocol comprises the simultaneous delivery of electrical impulses to two different brain areas of said living being, wherein said first brain area is the subthalamic nucleus (STN) and said second brain area is the substantia nigra pars reticulate (SNr), and said second DBS protocol comprises the delivery of electrical impulses to one brain area of said living being, wherein said one brain area is the subthalamic nucleus (STN), and
- wherein said control unit alternates between said first and second DBS protocols when the activity state of said living being is changed from a first state to a second state, said first state comprising the waking state, or activity state, or waking and activity states and said second state comprising the sleeping state, or resting state, or sleeping and resting states.
3 more elements
Dependencies are inferred from the claim text.