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US 9,283,357 B2Granted
Methods, compositions and apparatus for delivering heterologous molecules to cells
AssigneeThe Trustees of the University of Pennsylvania
InventorsHansell H. Stedman, Charles R. Bridges
Life of this patent
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Abstract
A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex.
Claims20
A method for transferring a macromolecular complex to muscle cells in a subject, said method comprising the steps of
- exsanguinating a region of the subject's microvasculature;
- delivering a macromolecular complex to the exsanguinated region of the subject's microvasculature under high hydrostatic pressure that transfers the complex to the muscle cells.
Dependencies are inferred from the claim text.