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US 9,283,302 B2Granted
Extracellular matrix encasement structures and methods
AssigneeCorMatrix Cardiovascular, Inc.
InventorRobert G Matheny
Life of this patent
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Abstract
A remodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region and at least one lead conduit, the internal region being configured to receive a device therein, the lead conduit being configures to receive at least one device lead therein, the bioremodelable material comprising an extracellular matrix (ECM) composition that includes an ECM component derived from a mammalian source.
Claims4
An implantable medical device, comprising:
- a coated pacemaker comprising an outer surface having at least one coating comprising an extracellular matrix (ECM) composition disposed thereon, said ECM composition coating forming a sealed ECM encasement structure,
- said ECM composition comprising acellular first ECM from a first mammalian tissue source, said first mammalian tissue source being selected from the group consisting of small intestine submucosa (SIS), urinary bladder submucosa (UBS) and stomach submucosa (SS), said ECM composition further comprising a first bioactive component comprising a statin and a second bioactive component comprising an anti-viral agent, said statin being dispersed within said first ECM,
- said coated pacemaker, when implanted in host tissue of a subject's body, being configured to modulate said subject's heart rate and induce modulated healing, said modulated healing comprising control of inflammation of said host tissue and induced tissue proliferation and bioremodeling of said host tissue.
Dependencies are inferred from the claim text.