Injectable hydrogels
AssigneeWilliam Marsh Rice University
InventorsAntonios G. Mikos, F. Kurtis Kasper, Adam K. Ekenseair, Tiffany N. Vo, Kristel W. M. Boere, Tyler J. Touchet
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Abstract
The present disclosure generally relates to injectable compositions. More particularly, the present disclosure relates to injectable, thermogelling hydrogels and associated methods. In one embodiment, the present disclosure provides for a composition comprising a poly(N-isopropylacrylamide)-based macromer and a polyamidoamine-based macromer.
Claims16
A composition comprising a poly(N-isopropylacrylamide)-based macromer and a diamine-based macromer, wherein the poly(N-isopropylacrylamide)-based macromer has a polymer backbone comprising glycidyl methacrylate (GMA) and N-isopropylacrylamide (NiPAAm), and wherein the poly(N-isopropylacrylamide)-based macromer is cross-linked by the diamine-based macromer via the GMA of the poly(N-isopropylacrylamide)-based macromer and an amine functional group of the diamine-based macromer.
A method comprising:
- combining a poly(N-isopropylacrylamide)-based macromer with a diamine-based macromer to form a composition, wherein the poly(N-isopropylacrylamide)-based macromer has a polymer backbone comprising glycidyl methacrylate (GMA) and N-isopropylacrylamide (NiPAAm);
- and
- injecting the composition into a defect in a mammal immediately following combining the poly(N-isopropylacrylamide)-based macromer with a diamine-based macromer.
Dependencies are inferred from the claim text.