Use of conjugates of hyaluronic acid in the local treatment of hyperproliferative skin diseases

A method of treating KA (actinic keratosis) with a conjugate of hyaluronic acid (HA) or a derivative thereof and paclitaxel, without systemic absorption of said paclitaxel, which comprises the topical administration of said conjugate to a patient in need thereof, wherein said conjugate comprises a conjugated ester formed at carboxyl groups of HA with a bromobutyric spacer and a substitution degree of 20% w/w, and wherein said conjugate remains only at the location of the lesion that is treated with said topical administration, whereby systemic accumulation of said conjugate is avoided.