US 9,283,283 B2 · Hyaluronic acid based hydrogel and use thereof in surgery

Abstract

The present invention relates to hydrogels based on hyaluronic acid based derivatives, that are more resistant than hyaluronic acid alone towards chemical and enzymatic degradation and are endowed with a mix of chemical and mechanical properties such that they are of optimal use in several surgeries, for instance for injection in bone fractures or cavities and for the production of coatings of prostheses in orthopedic surgery, as fillers in cosmetic and maxillo-facial surgery, as anti-adhesion barrier in the prevention of postoperative adhesions in abdominal and abdominal/pelvic surgery, and in general surgery. These hydrogels can be loaded with several different kinds of compounds having pharmacological and biological activity, that are then released from the hydrogel in the site of intervention.

Claims16

Dependent claims

A hydrogel comprising water and a hyaluronic acid derivative, wherein:

the hyaluronic acid derivative comprises hyaluronic acid (HA), or a salt thereof, of molecular weight comprised between 50,000 and 3,500,000 Da, onto the N-acetyl-D-glucosamine moieties of which are grafted chains of a biodegradable and biocompatible polyester of molecular weight comprised between 3,000 and 900,000 Da, in an amount such that the derivative comprises between 1 and 50 of said polyester chains per 100 repeating units of D-glucuronic acid/N-acetyl-D-glucosamine of hyaluronic acid;
the concentration of said hyaluronic acid derivative in the hydrogel is between 2 and 10% w/v, and
the hydrogel has a shelf life of at least 6 month at ambient temperature.

Dependencies are inferred from the claim text.

Facts

Application

13/813,422Filed 29 Jul 2011

Priority

IT MI2010A145130 Jul 2010

Published

US 2013/0129800 A123 May 2013

Granted

15 Mar 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

A61K 47/36
Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates: polysaccharides; Derivatives thereof, e.g. gums, starch, alginate,…
A61L 27/20
Macromolecular materials: polysaccharides
A61L 27/34
Materials for coating prostheses: macromolecular materials
A61L 27/52
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…

Hyaluronic acid based hydrogel and use thereof in surgery

Life of this patent

Hyaluronic acid based hydrogel and use thereof in surgery

Life of this patent

Abstract

Claims16