Sustained release polymer
AssigneeTolmar Therapeutics, Inc.
InventorRichard L. Dunn
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Abstract
A polymer and a method for its preparation are provided. The polymer comprises poly(lactide), poly(lactide/glycolide) or poly(lactic acid/glycolic acid) segments bonded by ester linkages to both ends of an alkanediol core unit. The polymer is for use in a controlled release formulation for a medicament, preferably leuprolide acetate. The controlled release formulation is administered to a patient as a subcutaneous depot of a flowable composition comprising the polymer, a biocompatible solvent, and the medicament. Controlled release formulations comprising the polymer release leuprolide for treatment of prostate cancer patients over periods of 3-6 months.
Claims18
A composition suitable for treatment of prostate cancer, comprising a polyester, N-methyl pyrrolidone and leuprolide acetate, wherein the polyester comprises two poly(lactide-co-glycolide) segments covalently bonded through their terminal carboxyl groups to 1,6-hexane diol as a core unit so that the polyester is PLG-COO—(CH2)6—OOC-PLG.
Dependencies are inferred from the claim text.