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US 9,283,279 B2Granted
Targeted polymeric conjugates and uses thereof
AssigneesRamot at Tel-Aviv University Ltd., Universita' Degli Studi Di Padova
InventorsRonit Satchi-Fainaro, Gianfranco Pasut
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Abstract
Polymeric conjugates comprising a polymeric backbone having attached thereto a bone targeting moiety and a therapeutically active agent, wherein the bone targeting moiety is attached to one end of the polymeric backbone via a branching unit such that a molar ratio of the bone targeting moiety to the polymer is at least 2:1, are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.
Claims8
A conjugate having the structure:
- wherein n is an integer that ranges from 10 to 1000.
A conjugate having the structure:
- wherein n is an integer that ranges from 10 to 1000,
- wherein X is a lysine residue coupled to a labeling agent.
Dependencies are inferred from the claim text.