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US 9,283,277 B2Granted
Methods and compositions for the treatment of obesity
AssigneeChildren's Medical Center Corporation
InventorsUmut Ozcan, Lale Ozcan
Life of this patent
Estimating the term…
Abstract
The invention relates to methods and compositions for the treatment of obesity. The methods and compositions relate to the use of an agent that reduces or prevents endoplasmic reticulum stress in conjunction with leptin.
Claims17
A method of treating obesity in a human expressing endogenous leptin and exhibiting decreased sensitivity to the leptin comprising:
- administering to the human exhibiting decreased sensitivity to leptin an effective amount of an agent that is a chemical chaperone which reduces or prevents endoplasmic reticulum stress to increase sensitivity of the human to leptin;
- and administering an effective amount of leptin to cause weight loss.
Dependencies are inferred from the claim text.