US 9,283,276 B2 · Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof

Abstract

The present invention relates to antibodies, particularly antibody 175, and fragments thereof or antibodies derived therefrom, which bind to the EGF receptor, particularly to amplified or overexpressed epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. These antibodies are useful in the diagnosis and treatment of cancer. Recombinant or hybrid antibodies having the variable region heavy or light chain sequence(s) of antibody 175 are also provided. The antibodies of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Claims18

Dependent claims

An isolated antibody or an antigen-binding fragment thereof which recognizes an EGFR epitope which is found in tumorigenic, hyperproliferative or abnormal cells and not detectable in normal cells, wherein said antibody or fragment thereof does not recognize the junctional peptide LEEKKGNYVVTDH (SEQ ID NO:

13), said antibody or fragment thereof having light chain variable region CDR 1, 2, and 3 sequences comprising SEQ ID NOs:
1-3, respectively, and heavy chain variable region CDR 1, 2, and 3 sequences comprising SEQ ID NOs:
4-6, respectively.

Dependencies are inferred from the claim text.

Facts

Application

12/733,146Filed 14 Aug 2008 · us provisional application

Priority

14 Aug 2007

Published

US 2011/0150759 A123 Jun 2011

Granted

15 Mar 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61K 39/395
Medicinal preparations containing antigens or antibodies: antibodies ; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00
Antineoplastic agents
A61P 35/04
Antineoplastic agents: specific for metastasis

Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof

Life of this patent

Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof

Life of this patent

Abstract

Claims18