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US 9,283,274 B2Granted
RSV specific binding molecule
AssigneeMedImmune, LLC
InventorsTim Beaumont, Adrianus Q. Bakker, Etsuko Yasuda
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Abstract
The invention provides antibodies and functional equivalents thereof which are capable of specifically binding RSV. Nucleic acid sequences encoding said antibody, as well as antibody producing cells and methods for producing said antibody are also provided.
Claims34
An isolated nucleic acid molecule comprising:
- a nucleic acid sequence encoding a heavy chain CDR1 comprising the amino acid sequence KLSIH (SEQ ID NO:4), and/or
- a nucleic acid sequence encoding a heavy chain CDR2 comprising the amino acid sequence GYEGEVDEIFYAQKFQH (SEQ ID NO:8), and/or
- a nucleic acid sequence encoding a heavy chain CDR3 comprising the amino acid sequence LGVTVTEAGLGIDDY (SEQ ID NO:12), and/or
- a nucleic acid sequence encoding a light chain CDR1 comprising the amino acid sequence RASQIVSRNHLA (SEQ ID NO:20), and/or
- a nucleic acid sequence encoding a light chain CDR2 comprising the amino acid sequence GASSRAT (SEQ ID NO:24), and/or
- a nucleic acid sequence encoding a light chain CDR3 comprising the amino acid sequence LSSDSSI (SEQ ID NO:28).
3 more elements
An isolated nucleic acid molecule comprising:
- a nucleic acid sequence encoding a heavy chain CDR1 sequence comprising the sequence KLSIH (SEQ ID NO:4);
- and
- a nucleic acid sequence encoding a heavy chain CDR2 sequence comprising the sequence GYEGEVDEIFYAQKFQH (SEQ ID NO:8), and
- a nucleic acid sequence encoding a heavy chain CDR3 sequence comprising the sequence LGVTVTEAGLGIDDY (SEQ ID NO:12), and
- a nucleic acid sequence encoding a light chain CDR1 sequence comprising the sequence RASQIVSRNHLA (SEQ ID NO:20), and
- a nucleic acid sequence encoding a light chain CDR2 sequence comprising the sequence GASSRAT (SEQ ID NO:24), and
- a nucleic acid sequence encoding a light chain CDR3 sequence comprising the sequence LSSDSSI (SEQ ID NO:28);
- and
- a nucleic acid sequence encoding a human IgG1 constant region;
- wherein the human IgG1 constant region comprises a tyrosine at amino acid position 252, a threonine at amino acid position 254, and a glutamic acid at amino acid position 256, said amino acid positions as numbered by the EU index of Kabat.
7 more elements
Dependencies are inferred from the claim text.