Bordetella outer-membrane protein antigens and methods of making and using the same
AssigneeWake Forest University Health Sciences
InventorsRajendar K. Deora, Meenu Mishra, Neelima Sukumar
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Abstract
An isolated protein or peptide selected from the group consisting of Bordetella colonization factor A (BcfA) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need thereof by administering the proteins, peptides or antibodies, and pharmaceutical compositions comprising the same.
Claims4
A method of treating a mammalian subject for a Bordetella infection, comprising administering said subject an antibody in a treatment effective amount, wherein said antibody binds to Bordetella colonization factor A (BcfA) protein fragment consisting of 20 to 500 consecutive amino acids of either SEQ ID NO:
- 2 or SEQ ID NO:3.
Dependencies are inferred from the claim text.