Metastasis inhibition preparations and methods
AssigneeUniversity of Notre Dame
InventorsMark A. Suckow, William R. Wolter, Valerie Sailes
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Abstract
Disclosed are compositions and pharmaceutical preparations suitable for inhibiting metastasis of a malignant cancer in an animal. Methods for inhibiting and/or eliminating metastasis in an animal are also provided. In some embodiments, the preparations and compositions comprise a whole cell tumor preparation comprising tumor tissue cells and tumor connective tissue stroma. The disclosure also provides methods for preparing the preparations and pharmaceutical preparations. Inhibition of metastasis of malignant prostate cancer to the lung is shown in vivo.
Claims9
A method for inhibiting prostate tumor metastasis in an animal comprising:
- administering to an animal having a metastatic prostate tumor a composition comprising a prostate tumor cell preparation;
- and
- inhibiting prostate tumor metastasis to the lung,
- wherein said prostate tumor cell preparation is inactivated with a chemically deactivating substance comprising glutaraldehyde and is non-malignant and comprises tumor tissue cells and tumor connective tissue stroma.
A method for inhibiting pulmonary metastasis of a prostate cancer in an animal comprising:
- administering to an animal having prostate cancer a composition comprising a prostate tumor cell preparation;
- and
- inhibiting pulmonary metastasis of the cancer in the treated animal,
- wherein said prostate tumor cell preparation is chemically treated with a preparation comprising glutaraldehyde.
Dependencies are inferred from the claim text.