US 9,283,261 B2Granted

Linaclotide compositions

AssigneeForest Laboratories Holdings Limited

InventorsRitesh Sanghvi, Matthew Miller, Andreas Grill, Yun Mo, Mohammad Mafruhul Bari, Matthew Ronsheim, Joseph Stainkamp

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Abstract

The present invention is directed to stable linaclotide compositions and methods of treating gastrointestinal disorders in patients in need thereof by providing the stable linaclotide compositions.

Claims22

Dependent claims

A linaclotide composition comprising linaclotide, a sterically hindered primary amine, a divalent metal cation and a formaldehyde scavenger compound and further comprises a peptide having the structure of formula (I) or a pharmaceutically acceptable salt thereof (SEQ ID NO:

Dependencies are inferred from the claim text.

Facts

Application: 14/489,718Filed 18 Sep 2014 · continuation
Priority: 12 Jul 2012
Published: US 2015/0005241 A11 Jan 2015
Granted: 15 Mar 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61K 47/22
Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite: heterocyclic compounds, e.g.…
A61K 9/0053
Galenical forms characterised by the site of application: mouth and digestive tract, i.e. intraoral and peroral administration
A61K 9/1676
With an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface: having a drug-free core…
A61K 9/5015
Wall or coating material: organic compounds, e.g. fats, sugars

Family

Application61/670,875Us provisional application · filed 12 Jul 2012
Application13/799,982Parent of this continuation · filed 13 Mar 2013
US 2015/0005241 A1Pre-grant publication · published 1 Jan 2015
US 2014/0018307 A1Published application
US 9,283,261 B2This patent

From the US filing history. Foreign family members aren’t listed.

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