Lyophilized therapeutic peptibody formulations

A stable lyophilized therapeutic peptibody composition comprising a buffer, a bulking agent, a stabilizing agent, and a surfactant wherein;

• said buffer is 10 mM histidine;
• the pH is 5.0;
• said bulking agent is 4% w/v mannitol;
• said stabilizing agent is 2% w/v sucrose;
• said surfactant is 0.004% w/v polysorbate-20;
• and
• said therapeutic peptibody is a dimer that comprises a structure of the formula
• F1-(L1)e-P1(L2)f-P2
• wherein:
• F1 is an Fc domain, wherein the Fc domain is attached at the N-terminus of -L1-P1-L2-P2;
• P1 and P2 are each independently selected from Table 6;
• L1 and L2 are each independently linkers;
• and
• e and f are each independently 0 or 1.