Antibacterial composition comprising Salvia extracts
AssigneeBotanic Century (Beijing) Co. Ltd.
InventorZhong Zhong
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Abstract
The present invention relates to a selectively purified tanshinone compounds containing extract from the root of a Salvia spp comprising Cryptotanshinone, Dihydrotanshinone, Tanshinone I, and Tanshinone IIA. It comprises at least 15%, by weight of the said identified tanshinone compounds and at least 4% by weight, of cryptotanshinone. The extract and formulations thereof have been found to exhibit excellent anti-microbial properties against, in particular MRSA.
Claims20
A topical gel formulation having antibacterial activity comprising a selectively purified extract from the root of a Salvia spp comprising the identified tanshinone compounds
- Cryptotanshinone,
- Dihydrotanshinone,
- Tanshinone I, and
- Tanshinone IIA,
- said extract characterized in that the extract has antibacterial activity at a level of 16 micrograms per milliliter or less in the gel formulation and the identified tanshinone compounds comprise at least 35% by weight of the selectively purified extract;
- the cryptotanshinone is the dominant tanshinone compound and comprises at least 15% by weight of the selectively purified extract and at least 40% by weight of the total identified tanshinone compounds;
- the tanshinone IIA comprises less than 50% by weight of the total identified tanshinone compounds;
- and said extract has antibacterial activity against at least one drug resistant bacterium.
A topical gel formulation having antibacterial activity comprising a selectively purified extract from the root of a Salvia spp comprising the identified tanshinone compounds
- Cryptotanshinone,
- Dihydrotanshinone,
- Tanshinone I, and
- Tanshinone IIA,
- said extract characterized in that the extract has antibacterial activity at a level of 16 micrograms per milliliter or less in the gel formulation and the selectively purified extract comprises 34.31 to 51.47% by weight of the identified tanshinone compounds and has a cryptotanshinone content of 15.16 to 22.74% by weight, a dihydrotanshinone content of 2.92 to 4.38% by weight, a tanshinone I content of 3.06 to 4.58% by weight, and a tanshinone IIA content of 13.18 to 19.76% by weight all based on the total weight of the extract;
- and said extract has antibacterial activity against at least one drug resistant bacterium.
Dependencies are inferred from the claim text.