Chemically modified dendrimers

A method of treating arthritis or reducing a symptom associated with arthritis, the method comprising administering to a subject an effective amount of a dendrimer, said dendrimer comprising a plurality of branched repeating units radiating out from a central atom, multifunctional moiety, or cluster of atoms, wherein each repeating unit comprises a terminal moiety, and wherein at least about 5% of the terminal moieties include a urea of formula (I)

• wherein
• each R1 and R2 is independently C1-C6 alkyl, C1-C6 alkenyl, cyclyl, aryl, heterocyclyl, heteroaryl, cyclylalkyl, arylalkyl, or heterocyclylalkyl, heteroarylalkyl;
• any of which are optionally substituted by C1-C6 alkyl, amino, C1-C6 alkylamino, C1-C6 dialkylamino, hydroxy, C1-C6 alkoxy, and wherein either of R1 or R2 independently optionally have a net charge;
• indicates the point of attachment of the terminal moiety of formula (I) to the dendrimer;
• and
• wherein less than about 12% of the terminal moieties are covalently bound to a saccharide moiety.