Back to results
US 9,283,244 B2Granted
Treatment of cancer by inhibiting activity or expression of late SV-40 factor
AssigneeVirginia Commonwealth University
InventorsDevanand Sarkar, Paul B. Fisher
Life of this patent
Estimating the term…
Abstract
Inhibitors of Late SV-40 Factor (LSF) are used to treat cancers such as hepatocellular carcinoma (HCC). In particular, small molecule chemical LSF inhibitors are employed. In addition, the activity and/or pattern of expression of LSF may is used to diagnose cancer, to characterize the cancer (e.g. stage, grade, prognosis, etc.) and also to develop suitable protocols for cancer treatment.
Claims6
A method of inhibiting or reducing tumor growth associated with cancer in vivo in a subject, comprising the step of
- limiting expression or activity of Late SV40 Factor (LSF) activity in vivo in said subject, wherein said LSF inhibitor compound targets at least one DNA binding domain of LSF.
A method of promoting damage or death of cancer cells in vivo in a subject, comprising the step of
- limiting expression or activity of Late SV40 Factor (LSF) activity in vivo in said subject, and wherein said step of limiting includes a step of administering to said subject one or more of an LSF inhibitor compound, anti-LSF inhibitory RNA, and anti-LSF antibodies, and wherein said LSF inhibitor compound targets at least one DNA binding domain of LSF.
Dependencies are inferred from the claim text.