Uses of dihydro bases
AssigneeMassachusetts Institute of Technology
InventorsJohn M. Essigmann, Deyu Li, Katherine J. Silvestre
Life of this patent
Estimating the term…
Abstract
The present invention provides pharmaceutical compositions comprising a dihydro base described herein (e.g., compound DHdC). The dihydro base may show multiple tautomerism and may increase mutation of an RNA and/or DNA of a virus or cancer cell. The dihydro base may be used to reduce DNA methylation (e.g., in a cancer cell). The present invention also provides kits including the inventive pharmaceutical compositions and methods of treating a viral infection (e.g., influenza, HIV infection, or hepatitis C) or cancer using the pharmaceutical compositions or kits.
Claims10
A method of treating a viral infection in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising:
- a compound of the formula:
- or a pharmaceutically acceptable salt thereof;
- and
- optionally a pharmaceutically acceptable excipient.
A method of increasing the mutation rate of a RNA of a virus, the method comprising contacting the virus with an effective amount of a pharmaceutical composition comprising:
- a compound of the formula:
- or a pharmaceutically acceptable salt thereof;
- and optionally a pharmaceutically acceptable excipient;
- and optionally an additional pharmaceutical agent.
A method of killing a virus, the method comprising contacting the virus with an effective amount of a pharmaceutical composition comprising:
- a compound of the formula:
- or a pharmaceutically acceptable salt thereof;
- and optionally a pharmaceutically acceptable excipient;
- and optionally an additional pharmaceutical agent.
A method of inhibiting replication of a virus, the method comprising contacting the virus with an effective amount of a pharmaceutical composition comprising:
- a compound of the formula:
- or a pharmaceutically acceptable salt thereof;
- and optionally a pharmaceutically acceptable excipient;
- and optionally an additional pharmaceutical agent.
A method of increasing the mutation rate of a DNA of a virus, the method comprising contacting the virus with an effective amount of a pharmaceutical composition comprising:
- a compound of the formula:
- or a pharmaceutically acceptable salt thereof;
- and optionally a pharmaceutically acceptable excipient;
- and optionally an additional pharmaceutical agent.
Dependencies are inferred from the claim text.