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US 9,283,236 B2Granted
Aldosterone induced vascular elastin production
AssigneesThe Hospital for Sick Children, Human Matrix Sciences, LLC
InventorsAleksander Hinek, Thomas F. Mitts
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Abstract
Compositions and methods for inducing the deposition of elastin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.
Claims12
A method of treating cardiac dysfunction in a subject with a post-infarct heart comprising:
- administering an effective amount of aldosterone and an effective amount of spironolactone to said subject.
A method of improving the ejection fraction in a post-infarct heart of a subject comprising:
- administering an effective amount of aldosterone and an effective amount of spironolactone to said subject.
Dependencies are inferred from the claim text.