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US 9,283,225 B2Granted
Pyrido-pyrimidine derivatives
AssigneeMerck Patent GmbH
InventorsWolfgang Staehle, Oliver Schadt, Christine Knuehl, Manja Friese-Hamim, Bayard R. Huck, Andreas Goutopoulos, Nadia Brugger
Life of this patent
Estimating the term…
Abstract
Compounds of the formula I in which Het, R3 and R4 have the meanings indicated in Claim 1, are inhibitors of RON and can be employed, for the treatment of cancer.
Claims13
A compound of the formula I
- in which:
- Het denotes imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl or triazolyl, each of which is substituted by R1 and R2,
- R1 denotes Ar1,
- R2 denotes A′,
- R3 denotes F or Cl,
- R4 denotes H, CH2Ar2 or A,
- Ar1 denotes phenyl, which is unsubstituted or mono-, di- or trisubstituted by A, OH, OA, CONH2, COOH, COOA, CN, CHO, COA, SO2A, NHCOA and/or, SO2NH2,
- Ar2 denotes phenyl, which is unsubstituted or mono-, di- or trisubstituted by A, OH, OA, CONH2, COOH, COOA, CN, CHO, COA, SO2A, NHCOA and/or, SO2NH2,
- A′ denotes unbranched or branched alkyl having 1-6 C atoms, in which 1-7 H atoms may be replaced by F,
- A denotes unbranched or branched alkyl having 1-10 C atoms, in which one or two non-adjacent CH and/or CH2 groups may be replaced by N, O, S atoms and/or by —CH═CH— groups and/or in addition 1-7 H atoms may be replaced by F,
- and pharmaceutically usable salts, tautomers and stereoisomers thereof.
8 more elements
Dependencies are inferred from the claim text.