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US 9,283,222 B2Granted
Inhibitors of poly(ADP-ribose)polymerase
AssigneeAbbVie Inc.
InventorsVirajkumar B. Gandhi, Vincent L. Giranda, Jianchun Gong, Thomas D. Penning, Gui-Dong Zhu
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Abstract
Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
Claims3
A method of treating leukemia, colon cancer, carcinomas of the breast, or cervical carcinomas in a mammal comprising administering thereto a therapeutically acceptable amount of a compound of selected from the group consisting of
- 4-(3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl)-5,6,7,8-tetrahydrophthalazin-1(2h)-one;
- 4-((2-fluoro-5-((4-oxo-3,4,5,6,7,8-hexahydrophthalazin-1-yl)methyl)phenyl)amino)-4-oxobutanoic acid;
- and
- 1-(2-fluoro-5-((4-oxo-3,4,5,6,7,8-hexahydrophthalazin-1-yl)methyl)phenyl)pyrrolidine-2,5-dione;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.