Compositions of opioid antagonists and methods for treating conditions caused by the varicella-zoster virus therewith
AssigneeImuneks Farma Ilac Sanayi Ve Ticaret Anonim Sirketi Pak Is Merkezi
InventorsIbrahim Mustafa Iskender Pisak, Semra Bingol, Mehmet Levent Selamoglu, Mehmet Pisak
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Abstract
Provided are compositions comprising opioid antagonists, such as naltrexone naloxone, or nalmefene, or their pharmaceutically acceptable salts, and methods for treating conditions caused by the varicella-zoster virus therewith.
Claims29
A method for treating a vesicular eruption caused by the varicella-zoster virus, the method comprising topically administering to a subject in need thereof an effective amount of naltrexone or a pharmaceutically-acceptable salt thereof, wherein the naltrexone or the pharmaceutically-acceptable salt thereof is administered in the form of a pharmaceutical composition comprising:
- a) the naltrexone or the pharmaceutically-acceptable salt thereof in an amount of about 0.1% to about 5% by weight of the pharmaceutical composition;
- b) an emulsifying agent in an amount of about 2% to about 5% by weight of the pharmaceutical composition;
- c) a stiffening agent in an amount of about 1% to about 45% by weight of the pharmaceutical composition;
- d) a surfactant in an amount of about 0.5% to about 2.5% by weight of the pharmaceutical composition;
- e) a preservative in an amount of about 0.01% to about 0.6% by weight of the pharmaceutical composition;
- f) a humectant in an amount of about 1% to about 15% by weight of the pharmaceutical composition;
- g) alkalizing or buffering agent in an amount of about 0.01% to about 3% by weight of the pharmaceutical composition;
- h) an emollient in an amount of about 1% to about 50% by weight of the pharmaceutical composition;
- and
- i) a solvent,
- wherein the vesicular eruption regresses within 5 days of administration of the pharmaceutical composition.
Dependencies are inferred from the claim text.