Methods and compositions for improving cognitive function
AssigneeMars, Incorporated
InventorsStephen French, Amar P. Inamdar, Ian Andrew Macdonald, Susan T. Francis
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Abstract
This invention relates to compositions, and methods of use thereof, for (i) enhancing executive cognitive function(s) (for example, decision making, planning, working memory, multitasking, judgment, numerical problem-solving, reading comprehension), and/or (ii) increasing blood flow in brain vasculature, comprising administering to a subject in need thereof, certain polyphenols such as flavanols, procyanidins, or pharmaceutically acceptable salts or derivatives thereof.
Claims17
A method of enhancing executive cognitive function in a subject in need thereof comprising administering to the subject a composition including an effective amount of at least 50 mg per unit dose and/or serving of a component selected from the group consisting of one or more of the following:
- epicatechin, a pharmaceutically acceptable salt of epicatechin, at least one compound having the formula A, and a pharmaceutically acceptable salt thereof:
- wherein
- n is an integer from 2 to 18;
- X has either α or β stereochemistry;
- R has α stereochemistry and is OH;
- the 3,4-dihydroxyphenyl moiety of formula A has α stereochemistry;
- the substituents of C-4, C-6 and C-8 are X, Z and Y, respectively, and bonding of monomeric units occurs at C-4, C-6 or C-8;
- when any C-4, C-6 or C-8 is not bonded to another monomeric unit, X, Y and Z are hydrogen;
- and wherein the subject is not suffering from a neurodegenerative disease.
A method of increasing blood flow in brain vasculature in a healthy subject in need thereof comprising administering to the subject a composition including an effective amount of at least 50 mg per unit dose and/or serving of a component selected from the group consisting of one or more of the following:
- epicatechin, a pharmaceutically acceptable salt of epicatechin, at least one compound having the formula A, and a pharmaceutically acceptable salt thereof:
- wherein
- n is an integer from 2 to 18;
- X has either α or β stereochemistry;
- R has α stereochemistry and is OH;
- the 3,4-dihydroxyphenyl moiety of formula A has α stereochemistry;
- the substituents of C-4, C-6 and C-8 are X, Z and Y, respectively, and bonding of monomeric units occurs at C-4, C-6 or C-8;
- when any C-4, C-6 or C-8 is not bonded to another monomeric unit, X, Y and Z are hydrogen;
- and wherein the subject is not suffering from a neurodegenerative disease.
Dependencies are inferred from the claim text.